Abstract |
Reperfusion of ischemic myocardium may aggravate the ischemic state of injury and thus augment infarct size ( reperfusion injury). The aim of this study was to reduce infarct size by an intervention at the time of reperfusion that acts only on a reperfusion-specific pathomechanism. It was investigated whether SIN-1C, a metabolite of molsidomine, can protect against reperfusion injury in canine hearts in vivo. Ten anesthetized open chest dogs underwent 1 h of left anterior descendent artery (LAD) occlusion and were randomly assigned to receive either intracoronary SIN-1C or vehicle infusion as a placebo during the first hour of reperfusion. The infusion was adjusted to LAD flow to achieve a regional blood concentration of 5 x 10(-3) M. Infarct size was assessed by triphenyltetrazolium staining after 6 h of reperfusion. Left ventricular pressure (LVP) was similar in both groups ( SIN-1C: 101 +/- 6, placebo: 89 +/- 6 mm Hg, mean +/- SEM, n = 5) at the beginning of the experiment and did not change significantly thereafter from baseline values in both groups. During SIN-1C infusion, the LAD flow was increased ( SIN-1C: 195 +/- 38, control: 86 +/- 17 ml/min/100 g at 30 min of reperfusion, p < 0.05), while systemic hemodynamics remained unaltered. A reduction in infarct size (percent of area at risk) was seen in the SIN-1C group (11.4 +/- 2.8%) compared with the placebo group (24.4 +/- 3.9%, p < 0.05). Infusion of papaverin (5 x 10(-5) M) following an identical protocol caused a similar vasodilation as SIN-IC, but did not reduce infarct size in five additional dox experiments.(ABSTRACT TRUNCATED AT 250 WORDS)
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Authors | W Schlack, A Uebing, M Schäfer, F Bier, S Grunert, D Ebel, H M Piper, V Thämer |
Journal | Journal of cardiovascular pharmacology
(J Cardiovasc Pharmacol)
Vol. 25
Issue 3
Pg. 424-31
(Mar 1995)
ISSN: 0160-2446 [Print] United States |
PMID | 7769808
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Acetonitriles
- Morpholines
- SIN 1C
- Papaverine
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Topics |
- Acetonitriles
(metabolism, pharmacokinetics, pharmacology)
- Animals
- Coronary Circulation
(drug effects)
- Dogs
- Electrocardiography
(drug effects)
- Female
- Infusions, Intravenous
- Male
- Morpholines
(metabolism, pharmacokinetics, pharmacology)
- Myocardial Infarction
(etiology, pathology, physiopathology, prevention & control)
- Myocardial Ischemia
(pathology, physiopathology)
- Myocardial Reperfusion Injury
(complications, pathology, physiopathology)
- Myocardium
(pathology)
- Necrosis
(pathology)
- Papaverine
(pharmacology)
- Vasodilation
(drug effects)
- Ventricular Function, Left
(drug effects)
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