Myocardial perfusion imaging with technetium-99m-Tc NOET: comparison with thallium-201 and coronary angiography.

Abstract

UNLABELLED:

We compared TcN-NOET [bis(N-ethoxy, N-ethyl dithiocarbamato)nitrido 99mTc] and 201Tl images to estimate the utility of this compound in the detection of coronary artery disease (CAD).

METHODS:

Twenty-five patients undergoing cardiac catheterization had stress-redistribution-reinjection 201Tl SPECT imaging, stress-delayed (2, 4 and 6 hr postinjection) and rest-delayed (4 hr postinjection) TcN-NOET SPECT imaging.

RESULTS:

Nineteen patients had coronary stenosis > or = 50% and six were normal. Stress TcN-NOET and 201Tl imaging were concordant for the presence of CAD in 22/25 patients (88%, kappa = 0.76 +/- 0.20). The overall sensitivity of TcN-NOET SPECT imaging was 74% (14/19 patients) and 68% (13/19 patients) for 201Tl SPECT imaging. The specificity was 100% (6/6 patients) for both techniques. The overall agreement of TcN-NOET and 201Tl for the presence of disease in individual coronary arteries was 96% (72/75 arteries, kappa = 0.92 +/- 0.16). Segmental analysis of stress images showed a concordance in 211/225 segments (94%, kappa = 0.82 +/- 0.09). Comparison of the 4-hr images showed a concordance between 201Tl and TcN-NOET in 21/23 patients. Following TcN-NOET injection at rest, seven patients had a defect on the initial images, which had normalized 4 hr postinjection in four patients (57%).

CONCLUSION:

Perfusion imaging with TcN-NOET and 201Tl gives comparable diagnostic information in patients undergoing exercise testing for assessment of CAD. Because of the normalization of myocardial activity 4 hr after injection in some patients, we conclude that TcN-NOET is a potential technetium compound equivalent to 201Tl.

• Authors: D Fagret, P Y Marie, F Brunotte, M Giganti, D Le Guludec, A Bertrand, J E Wolf, A Piffanelli, F Chossat, D Bekhechi
• Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine (J Nucl Med) Vol. 36 Issue 6 Pg. 936-43 (Jun 1995) ISSN: 0161-5505 [Print] United States
• PMID: 7769449 (Publication Type: Comparative Study, Journal Article, Multicenter Study)

Chemical References

• Organotechnetium Compounds
• Thallium Radioisotopes
• Thiocarbamates
• technetium Tc 99m, bis(N-ethoxy-N-ethyldithiocarbamato)nitrido-

Topics

• Adult
• Aged
• Coronary Angiography
• Coronary Disease (diagnostic imaging)
• Exercise Test
• Female
• Heart (diagnostic imaging)
• Humans
• Male
• Middle Aged
• Organotechnetium Compounds
• Prospective Studies
• Radionuclide Imaging
• Sensitivity and Specificity
• Thallium Radioisotopes
• Thiocarbamates