Inhibitory peptides in hematopoiesis.

Abstract

This paper will review the present knowledge on two small chemically unrelated peptides, the pentapeptide pGlu-Glu-Asp-Cys-Lys (pEEDCK) and the tetrapeptide acetyl-N-Ser-Asp-Lys-Pro (AcSDKP, Seraspenide) focusing on 1) their inhibitory effects on normal hematopoiesis, 2) their effect on malignant cells, especially leukemic cells, and 3) their potential clinical use as marrow protectors during cancer therapy.

• Authors: M Guigon, D Bonnet
• Journal: Experimental hematology (Exp Hematol) Vol. 23 Issue 6 Pg. 477-81 (Jun 1995) ISSN: 0301-472X [Print] Netherlands
• PMID: 7768302 (Publication Type: Journal Article, Review)

Chemical References

• Oligopeptides
• hemoregulatory peptide 5b
• goralatide
• Pyrrolidonecarboxylic Acid

Topics

• Animals
• Hematopoiesis (drug effects)
• Hematopoietic Stem Cells (drug effects)
• Humans
• Oligopeptides (pharmacology)
• Pyrrolidonecarboxylic Acid (analogs & derivatives)