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Response of the human hepatic tissue cultures Hep-G2 and WRL-68 to cocaine.

Abstract
The hydrolytic metabolism of cocaine into benzoylecgonine, ecgonine methyl ester, and ecgonine was studied in the human hepatoma cell line Hep-G2 and in the nontumorigenic fetal hepatic cell line WRL-68. Also, the toxicological response of these cells to cocaine was compared to previously published results obtained with perfused liver cells and in vivo systems. Our experiments indicated that Hep-G2 appear to have similar metabolic and toxicological patterns to in vivo and perfused cell systems. The WRL-68 tissue culture system was found to be less similar. These results suggest Hep-G2 cells can be utilized to study cocaine metabolism and toxicology, and possibly in studies involving other xenobiotic compounds.
AuthorsP M Falk, R T Sabater, D D Carballo Jr
JournalJournal of pharmacological and toxicological methods (J Pharmacol Toxicol Methods) Vol. 33 Issue 2 Pg. 113-20 (Apr 1995) ISSN: 1056-8719 [Print] United States
PMID7766918 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • benzoylecgonine
  • ecgonine
  • Cocaine
  • ecgonine methyl ester
Topics
  • Carcinoma, Hepatocellular
  • Cell Death (drug effects)
  • Cell Division (drug effects)
  • Cell Line
  • Chromatography, Gas
  • Cocaine (analogs & derivatives, analysis, metabolism, toxicity)
  • Humans
  • Liver (cytology, drug effects, metabolism)
  • Mass Spectrometry
  • Tumor Cells, Cultured

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