Flunitrazepam for sleep disturbance in children with intractable epilepsy.

Abstract

Add-on therapy with flunitrazepam (FNZ) was performed in 5 children with marked sleep disturbance and intractable seizures. Correction of the sleep disturbance was attained immediately after the start of FNZ administration in all patients. Furthermore, a significant decrease in the seizure frequency (3 patients) and improved quality of life (4 patients) were concomitantly observed. There was no adverse effect or interaction with conventional AEDs on long-term use.

• Authors: T Konishi, K Masuko, Y Naganuma, K Hongou, S Yagi
• Journal: Brain & development (Brain Dev) 1995 Jan-Feb Vol. 17 Issue 1 Pg. 69-72 ISSN: 0387-7604 [Print] Netherlands
• PMID: 7762768 (Publication Type: Case Reports, Journal Article)

Chemical References

• Flunitrazepam

Topics

• Child
• Child, Preschool
• Epilepsy (complications)
• Flunitrazepam (therapeutic use)
• Humans
• Male
• Sleep Wake Disorders (drug therapy, etiology)