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FD&C Red No. 105 (Rose Bengal B) neutralizes the thyroid tumor promoting effect of iodine-deficient diet in rats.

Abstract
The effect of 3,4,5,6-tetrachloro-2',4',5',7'-tetraiodo-fluorescein sodium salt (Rose Bengal B or FD&C Red No. 105, molecular weight 1017.6) on the thyroid of rats treated with N-bis(2-hydroxypropyl)-nitrosamine (DHPN) and iodine-deficient (I-def) diet is studied. Six-week-old male F344 rats were divided into seven groups (20 each) and given a single subcutaneous injection of DHPN (2800 mg/kg body wt.). From week 2 to 20, I-def diet was given in combination with either FR105 (1.25, 5.0, or 20 mg/l) or potassium iodide (KI, 12.5, 50.0 or 200 micrograms/l) in drinking water. As a result, an amount of 1.25 mg/l of FR105 was slightly more effective than 200 micrograms/l of KI in terms of inhibition of the effect of I-def diet on thyroid weight, morphology, thyroid-related hormones and thyroid tumor development. It was calculated that 1 mumol/l of FR105 was slightly more potent than 1 mumol/l of iodide ion. As each FR105 molecule has four iodide residues, at least 25% of total iodide residues were calculated to be utilized by the rats given I-def diet.
AuthorsJ Kanno, Y Goda, K Sato, K Yoshihira, Y Hayashi
JournalToxicology (Toxicology) Vol. 99 Issue 1-2 Pg. 107-13 (May 05 1995) ISSN: 0300-483X [Print] Ireland
PMID7761994 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Carcinogens
  • Iodides
  • Potassium Iodide
  • Rose Bengal
  • Rose Bengal B
  • Iodine
Topics
  • Animals
  • Carcinogens (classification, pharmacology, toxicity)
  • Drug Interactions
  • Iodides (toxicity)
  • Iodine (deficiency)
  • Male
  • Potassium Iodide (pharmacology)
  • Rats
  • Rats, Inbred F344
  • Rose Bengal (analogs & derivatives, chemistry, pharmacology, toxicity)
  • Thyroid Neoplasms (chemically induced, etiology, prevention & control)

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