Effects of intracerebroventricular administration of N-acetylhistamine on body temperature in mice.

Abstract

The purpose of this study was to examine the effects of intracerebroventricular (i.c.v.) administration of N-acetylhistamine on rectal temperature, histamine level, histidine decarboxylase (HDC) activity, and the turnover rate of monoamines in mice. More than 60 micrograms of N-acetylhistamine induced hypothermia. The maximum effect of hypothermia was observed 20 min after administration of N-acetylhistamine (60-120 micrograms/mouse). A significant drop in rectal temperature of 3 degrees C was induced by 120 micrograms of N-acetylhistamine. Concurrent with the appearance of hypothermia, the histamine levels were increased. However, both histamine H1 and H2 antagonists did not prevent hypothermia. The i.c.v. administration of N-acetylhistamine inhibited HDC activity, but had no effect on the turnover rates of monoamines. These data confirmed that endogenous N-acetylhistamine may be a metabolite which lacks significant physiological roles, and demonstrated that exogenous N-acetylhistamine is not a good pharmacological tool for the study of the functions of the brain histaminergic system in mammals.

• Authors: K Onodera, H Shinoda, M Imaizumi, E Hiraki-Sakurai, A Yamatodani
• Journal: Methods and findings in experimental and clinical pharmacology (Methods Find Exp Clin Pharmacol) Vol. 16 Issue 8 Pg. 575-81 (Oct 1994) ISSN: 0379-0355 [Print] Spain
• PMID: 7760582 (Publication Type: Journal Article)

Chemical References

• Biogenic Monoamines
• N-acetylhistamine
• Histamine
• Histidine Decarboxylase

Topics

• Animals
• Biogenic Monoamines (metabolism)
• Body Temperature (drug effects)
• Brain Chemistry (drug effects)
• Histamine (administration & dosage, analogs & derivatives, blood, pharmacology)
• Histidine Decarboxylase (metabolism)
• Injections, Intraventricular
• Male
• Mice
• Mice, Inbred Strains