Effects of zaizhang-I, a traditional Chinese herbal medicine, on hematopoietic recovery from radiation injury in mice.

Abstract

Effects of Zaizhang-I (ZZ-I) on the recovery of hemopoietic systems from radiation injury were investigated. Mice, irradiated with 6.0 Gy-rays, were injected i.p. once daily for 7 consecutive days with either ZZ-I or saline (0.01 ml/g body wt.). The experiments showed that ZZ-I significantly promoted the recovery of not only peripheral WBC, BMC, CFU-S and CFU-GM but also the abnormal femur micro-vessel system such as blood vessels and sinus ectasia, hyperemia and hemorrhage etc. These results suggest that ZZ-I could accelerate hemopoietic recovery from radiation injury in mice by stimulating hemopoietic stem cells and improving hemopoietic inductive microenvironment (HIM).

• Authors: M W Yang, M D He, M Z Li
• Journal: Journal of Tongji Medical University = Tong ji yi ke da xue xue bao (J Tongji Med Univ) Vol. 14 Issue 4 Pg. 224-6 ( 1994) ISSN: 0257-716X [Print] China
• PMID: 7760433 (Publication Type: Journal Article)

Chemical References

• Drugs, Chinese Herbal
• zaizhang I

Topics

• Animals
• Drugs, Chinese Herbal (therapeutic use)
• Female
• Hematopoietic Stem Cells (drug effects)
• Mice
• Mice, Inbred BALB C
• Radiation Injuries, Experimental (drug therapy)