Anti-inflammatory activity of saikosaponins from Heteromorpha trifoliata.

Abstract

By means of activity-directed chromatographic fractionation using the 12-O-tetradecanoylphorbol acetate (TPA)-induced edema test, two saikosaponins were isolated from the MeOH extract of Heteromorpha trifoliata leaves. They were identified as 16 beta, 23-dihydroxy-13,28-epoxyolean-11-en-3 beta-yl-[beta-D-glucopyranosyl (1-->2)]-[beta-D-glucopyranosyl (1-->3)]-beta-D-fucopyranoside [1] and 16 beta, 23,28-trihydroxy-11 alpha-methoxyolean-12-en-3 beta-yl-[beta-D-glucopyranosyl (1-->2)]-[beta-D-glucopyranosyl (1-->3) [beta-D-fucopyranoside [2]. Compound 1 showed activity in the TPA and ethylphenylpropiolate (EPP) mouse ear edema and the serotonin paw edema tests, whereas compound 2 was active only in the mouse ear edema model. Both substances had only a slight effect against a carrageenan paw edema model. The anti-inflammatory action of compound 1 was notably decreased by the mRNA and protein synthesis inhibitors actinomycin D and cycloheximide.

• Authors: M C Recio, M J Just, R M Giner, S Mañez, J L Rios, K Hostettmann
• Journal: Journal of natural products (J Nat Prod) Vol. 58 Issue 1 Pg. 140-4 (Jan 1995) ISSN: 0163-3864 [Print] United States
• PMID: 7760072 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Sapogenins
• Saponins
• Oleanolic Acid
• saikosaponin D

Topics

• Animals
• Anti-Inflammatory Agents, Non-Steroidal (isolation & purification, pharmacology)
• Carbohydrate Sequence
• Female
• Malawi
• Mice
• Molecular Sequence Data
• Oleanolic Acid (analogs & derivatives)
• Plants, Medicinal (chemistry)
• Sapogenins (isolation & purification, pharmacology)
• Saponins