Gas chromatographic/mass spectrometric analyses of unknown analytical response in imported Fava beans: 4-chloro-6-methoxyindole.

Abstract

A halogenated unidentified analytical response (UAR) was encountered in a number of imported Fava bean samples during the Food and Drug Administration's routine pesticide-monitoring program. Gas chromatographic/mass spectrometric (GC/MS) analyses identified the halogenated component as 4-chloro-6-methoxyindole, a naturally occurring promutagen in Fava beans that has been linked to incidents of gastric cancer. Data from electron impact, positive and negative chemical ionization, collision-induced dissociation, and deuteration studies of this compound are presented, along with GC retention time data.

• Authors: G Petzinger, T L Barry, J A Roach, S M Musser, J Sphon
• Journal: Journal of AOAC International (J AOAC Int) 1995 May-Jun Vol. 78 Issue 3 Pg. 888-92 ISSN: 1060-3271 [Print] England
• PMID: 7756907 (Publication Type: Journal Article)

Chemical References

• Indoles
• 4-chloro-6-methoxyindole

Topics

• Fabaceae (chemistry)
• Gas Chromatography-Mass Spectrometry
• Indoles (chemistry, isolation & purification)
• Molecular Weight
• Plants, Medicinal