Suppression of heat-induced hsp70 expression by the 70-kDa subunit of the human Ku autoantigen.

Abstract	Expression of the 70-kDa polypeptide of human Ku autoantigen in rat cells is shown to suppress specifically the induction of hsp70 upon heat shock. Thermal induction of other heat shock proteins is not significantly affected, nor is the state of phosphorylation or the DNA-binding ability of the heat shock transcription factor HSF1. These findings support a model in which hsp70 gene expression is controlled by a second regulatory factor in addition to the positive activator HSF1. The Ku autoantigen, or a protein closely related to it, is likely to be involved in the regulation of hsp70 expression.
Authors	G C Li, S H Yang, D Kim, A Nussenzweig, H Ouyang, J Wei, P Burgman, L Li
Journal	Proceedings of the National Academy of Sciences of the United States of America (Proc Natl Acad Sci U S A) Vol. 92 Issue 10 Pg. 4512-6 (May 09 1995) ISSN: 0027-8424 [Print] United States
PMID	7753835 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References	Antigens, Nuclear Autoantigens DNA-Binding Proteins HSF1 protein, human HSP70 Heat-Shock Proteins Heat Shock Transcription Factors Hsf1 protein, rat Macromolecular Substances Nuclear Proteins Oligodeoxyribonucleotides Recombinant Proteins Transcription Factors DNA Helicases XRCC5 protein, human Xrcc6 protein, human Xrcc6 protein, rat Ku Autoantigen
Topics	Animals Antigens, Nuclear Autoantigens (metabolism) Base Sequence Binding Sites Blotting, Western Cell Line DNA Helicases DNA-Binding Proteins (biosynthesis, metabolism) Fibroblasts (cytology, metabolism) Gene Expression HSP70 Heat-Shock Proteins (antagonists & inhibitors, biosynthesis) Heat Shock Transcription Factors Humans Kinetics Ku Autoantigen Macromolecular Substances Molecular Sequence Data Nuclear Proteins (biosynthesis, metabolism) Oligodeoxyribonucleotides Rats Recombinant Proteins (biosynthesis, metabolism) Transcription Factors (metabolism) Transfection

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