Piroxicam-beta-cyclodextrin in induced migraine attacks: a SPECT study with Tc-99m HM-PAO split-dose method.

Abstract	To verify the effect of piroxicam-beta-cyclodextrin (P-B-CD), a novel non-steroidal anti-inflammatory compound, on regional cerebral blood flow (rCBF) during migraine attacks, 7 female patients (mean age: 37.4 years), suffering from migraine without aura, were studied. The patients, after induction of a migraine-like attack with sublingual nitroglycerin (NTG), underwent a rCBF evaluation using Single Photon Emission Computerized Tomography (SPECT) and Tc-99m examethyl-propylene-amino-oxyma split-dose method before and after oral administration of P-B-CD (20 mg). In addition, a spontaneous migraine attack and NTG test in 7 control subjects were investigated. All patients observed relief of pain, evaluated by direct and indirect parameters (Pain Intensity; Pain Intensity Difference; Sum of Pain Intensity Difference). SPECT revealed a uniform and symmetrical distribution of the radiocompound in 5 out of 8 patients, while in the remaining 3 symmetrical parietal or parieto-occipital areas of decreased tracer uptake were detected. In these cases, the intake of P-B-CD cancelled out the cerebral perfusion abnormality.
Authors	M Trucco, C Cananzi, P R Salvadori, R Badino
Journal	Functional neurology (Funct Neurol) 1994 Sep-Oct Vol. 9 Issue 5 Pg. 247-57 ISSN: 0393-5264 [Print] Italy
PMID	7750808 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Anti-Inflammatory Agents, Non-Steroidal Cyclodextrins Drug Combinations Organotechnetium Compounds Oximes beta-Cyclodextrins Piroxicam Technetium Tc 99m Exametazime piroxicam-beta-cyclodextrin Nitroglycerin
Topics	Adolescent Adult Anti-Inflammatory Agents, Non-Steroidal (therapeutic use) Blood Flow Velocity (drug effects) Brain (blood supply) Cyclodextrins (therapeutic use) Drug Combinations Female Humans Middle Aged Migraine Disorders (diagnostic imaging, drug therapy) Nitroglycerin Organotechnetium Compounds Oximes Pain Measurement Piroxicam (therapeutic use) Regional Blood Flow (drug effects) Technetium Tc 99m Exametazime Tomography, Emission-Computed, Single-Photon beta-Cyclodextrins

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!