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Autoimmune progesterone dermatitis: absence of contact sensitivity to glucocorticoids, oestrogen and 17-alpha-OH-progesterone.

Abstract
Autoimmune progesterone dermatitis is a rare condition, characterized by recurrent premenstrual exacerbations of a dermatosis, in which sensitivity to progesterone can be demonstrated. The sensitizing mechanism is unknown. The aim of this study was to test the hypothesis that cross-sensitivity between steroid groups could induce allergy to endogenous progesterone in these patients. 5 patients with autoimmune progesterone dermatitis and 1 with oestrogen-sensitive dermatitis have been patch tested with a corticosteroid series, conjugated oestrogen 1% in petrolatum (pet.), and 17-alpha-OH-progesterone 2% pet. There were no immediate or delayed reactions at 2 and 4 days to any steroid group. We have therefore been unable to demonstrate steroid cross-sensitivity, or a use for 17-alpha-OH-progesterone in the investigation of oestrogen - and progesterone-sensitive dermatoses.
AuthorsC J Stephens, J P McFadden, M M Black, R J Rycroft
JournalContact dermatitis (Contact Dermatitis) Vol. 31 Issue 2 Pg. 108-10 (Aug 1994) ISSN: 0105-1873 [Print] England
PMID7750249 (Publication Type: Journal Article)
Chemical References
  • Estrogens
  • Glucocorticoids
  • Hydroxyprogesterones
  • Progesterone
Topics
  • Adult
  • Autoimmune Diseases (diagnosis, immunology)
  • Dermatitis, Contact (diagnosis, immunology)
  • Drug Eruptions (diagnosis, etiology)
  • Estrogens (adverse effects, immunology)
  • Female
  • Glucocorticoids (adverse effects, immunology)
  • Humans
  • Hydroxyprogesterones (adverse effects, immunology)
  • Intradermal Tests
  • Patch Tests
  • Progesterone (immunology)

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