Abstract |
Rapid cell death, as evidenced by a decrease in cell counts, was observed when molt-4-lymphoblastoid cells, a human leukemia cell line, were exposed to holotransferrin (12 microM) and dihydroartemisinin (1-200 microM). Incubation with either compound alone was significantly less effective. Significantly less cell death was observed when normal human lymphocytes were exposed to a combination of these 2 drugs. Probit analysis of dose-response functions shows that the drug combination is approximately 100 times more effective on molt-4 cells than lymphocytes (LD50s for molt-4 and lymphocytes were 2.59 microM and 230 microM, respectively). This drug combination may provide a novel approach for cancer treatment.
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Authors | H Lai, N P Singh |
Journal | Cancer letters
(Cancer Lett)
Vol. 91
Issue 1
Pg. 41-6
(May 04 1995)
ISSN: 0304-3835 [Print] Ireland |
PMID | 7750093
(Publication Type: Journal Article)
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Chemical References |
- Artemisinins
- Drug Combinations
- Sesquiterpenes
- Transferrin
- holotransferrin
- artenimol
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Topics |
- Artemisinins
- Cell Survival
(drug effects)
- Dose-Response Relationship, Drug
- Drug Combinations
- Humans
- Lymphocytes
(drug effects)
- Precursor Cell Lymphoblastic Leukemia-Lymphoma
- Sesquiterpenes
- Time Factors
- Transferrin
(pharmacology)
- Tumor Cells, Cultured
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