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Selective cancer cell cytotoxicity from exposure to dihydroartemisinin and holotransferrin.

Abstract
Rapid cell death, as evidenced by a decrease in cell counts, was observed when molt-4-lymphoblastoid cells, a human leukemia cell line, were exposed to holotransferrin (12 microM) and dihydroartemisinin (1-200 microM). Incubation with either compound alone was significantly less effective. Significantly less cell death was observed when normal human lymphocytes were exposed to a combination of these 2 drugs. Probit analysis of dose-response functions shows that the drug combination is approximately 100 times more effective on molt-4 cells than lymphocytes (LD50s for molt-4 and lymphocytes were 2.59 microM and 230 microM, respectively). This drug combination may provide a novel approach for cancer treatment.
AuthorsH Lai, N P Singh
JournalCancer letters (Cancer Lett) Vol. 91 Issue 1 Pg. 41-6 (May 04 1995) ISSN: 0304-3835 [Print] Ireland
PMID7750093 (Publication Type: Journal Article)
Chemical References
  • Artemisinins
  • Drug Combinations
  • Sesquiterpenes
  • Transferrin
  • holotransferrin
  • artenimol
Topics
  • Artemisinins
  • Cell Survival (drug effects)
  • Dose-Response Relationship, Drug
  • Drug Combinations
  • Humans
  • Lymphocytes (drug effects)
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Sesquiterpenes
  • Time Factors
  • Transferrin (pharmacology)
  • Tumor Cells, Cultured

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