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Pyridoxine dependent epilepsy with iatrogenic sensory neuronopathy.

Abstract
An 18-year-old man was treated from birth with chronic high dose pyridoxine (vitamin B6) up to 2000 mg per day for pyridoxine-dependent seizures. Within two years of onset of treatment, he developed a sensory neuropathy which did not progress over the following 16 years. Electrophysiological studies were consistent with a pure sensory neuronopathy expressed as centripetal degeneration of processes of the dorsal root ganglion cells.
AuthorsR S McLachlan, W F Brown
JournalThe Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques (Can J Neurol Sci) Vol. 22 Issue 1 Pg. 50-1 (Feb 1995) ISSN: 0317-1671 [Print] England
PMID7750075 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Pyridoxine
Topics
  • Action Potentials
  • Adolescent
  • Electrophysiology
  • Epilepsy (drug therapy)
  • Ganglia, Spinal
  • Humans
  • Iatrogenic Disease
  • Male
  • Pyridoxine (adverse effects, pharmacology)
  • Seizures
  • Sensation Disorders
  • Tibia

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