[Allogenic bone marrow transplantation in Wiskott-Aldrich syndrome].

Abstract

Two males of 3 and 3 1/2 years of age with the Wiskott-Aldrich syndrome who underwent bone marrow transplantation from an HLA compatible brother following conditioning treatment with busulphan and cyclophosphamide are described. In both patients the taking of the graft was proven by study of blood subgroups and correction of the immunodeficiency, normalization of platelet number and function and disappearance of cutaneous eczema were seen. At 3 and 1 year respectively of the transplantation the patients showed no evidence of graft versus host disease and no severe infections or hemorrhagic episodes have seen.

• Authors: M S Maldonado, A Muñoz, E Otheo de Tejada, E Roldán, L Aymerich, J A Brieva
• Journal: Medicina clinica (Med Clin (Barc)) Vol. 101 Issue 7 Pg. 258-60 (Sep 11 1993) ISSN: 0025-7753 [Print] Spain
• Vernacular Title: Trasplante de medula ósea alogénico en el síndrome de Wiskott-Aldrich.
• PMID: 7746001 (Publication Type: Case Reports, English Abstract, Journal Article)

Topics

• Bone Marrow Transplantation
• Child, Preschool
• Humans
• Male
• Wiskott-Aldrich Syndrome (surgery)