Efficacy of the angiogenesis inhibitor O-(chloroacetyl-carbamoyl)fumagillol (AGM-1470) on osteosarcoma growth and lung metastasis in rats.

Abstract

The efficacy of the anti-angiogenic agent, O-(chloroacetyl-carbamoyl)fumagillol (AGM-1470), against primary tumor growth and spontaneous lung metastasis was evaluated experimentally using a transplantable osteosarcoma line in rats previously established in our laboratory. Male Fischer 344 rats bearing the tumor with a high potential for metastasis received intermittent or continuous subcutaneous administrations of AGM-1470. Both treatment regimens resulted in significant inhibitions of spontaneous lung metastasis and primary tumor growth in a dose-dependent manner, with continuous administration of AGM-1470 exerting the most pronounced inhibitory effects on both parameters.

• Authors: T Morishita, Y Mii, Y Miyauchi, S Miura, K Honoki, M Aoki, A Kido, S Tamai, M Tsutsumi, Y Konishi
• Journal: Japanese journal of clinical oncology (Jpn J Clin Oncol) Vol. 25 Issue 2 Pg. 25-31 (Apr 1995) ISSN: 0368-2811 [Print] England
• PMID: 7745819 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antibiotics, Antineoplastic
• Cyclohexanes
• Sesquiterpenes
• O-(Chloroacetylcarbamoyl)fumagillol

Topics

• Animals
• Antibiotics, Antineoplastic (administration & dosage, therapeutic use)
• Cyclohexanes
• Dose-Response Relationship, Drug
• Drug Evaluation, Preclinical
• Injections, Subcutaneous
• Lung Neoplasms (prevention & control, secondary)
• Male
• O-(Chloroacetylcarbamoyl)fumagillol
• Osteosarcoma (drug therapy)
• Rats
• Rats, Inbred F344
• Sesquiterpenes (administration & dosage, therapeutic use)
• Tumor Cells, Cultured