Inhibitory effects of cucurbitane triterpenoids on Epstein-Barr virus activation and two-stage carcinogenesis of skin tumor. II.

Abstract

To search for possible anti-tumor-promoters, we carried out a primary screening of twenty-four 29-nor-cucurbitacin glucosides isolated from the roots of Cayaponia tayuya (Cucurbitaceae) using an in vitro synergistic assay system. Of these glucosides, cayaponosides B (5), B3 (7), D (8), D3b (22) and C2 (23) exhibited significant inhibitory effects on Epstein-Barr virus (EBV) activation induced by the tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA). Furthermore, 5 and 23 exhibited remarkable anti-tumor-promoting effects on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test.

• Authors: T Konoshima, M Takasaki, M Kozuka, T Nagao, H Okabe, N Irino, T Nakasumi, H Tokuda, H Nishino
• Journal: Biological & pharmaceutical bulletin (Biol Pharm Bull) Vol. 18 Issue 2 Pg. 284-7 (Feb 1995) ISSN: 0918-6158 [Print] Japan
• PMID: 7742799 (Publication Type: Journal Article)

Chemical References

• Triterpenes

Topics

• Animals
• Drug Screening Assays, Antitumor
• Female
• Herpesvirus 4, Human (drug effects, growth & development)
• Mice
• Mice, Inbred ICR
• Papilloma (drug therapy)
• Skin Neoplasms (drug therapy)
• Triterpenes (chemistry, pharmacology)
• Virus Activation (drug effects)