Isolation of a previously unidentified polysaccharide (MAR-10) from Hyssop officinalis that exhibits strong activity against human immunodeficiency virus type 1.

Abstract

A polysaccharide (MAR-10) was isolated from the aqueous extract of the plant Hyssop officinalis and examined for its activity against HIV-1 (SF strain) in HUT78 T cell line and primary cultures of peripheral blood mononuclear cells. MAR-10, in a concentration-dependent manner, inhibited HIV-1 replication as demonstrated by the inhibition of HIV-1 p24 antigen and syncytia formation. Furthermore, MAR-10 had no significant direct toxicity or effect on lymphocyte functions or CD4+ and CD8+ T cell counts. In addition, MAR-10 has broad spectrum anti-glycosidase activity. Our study demonstrates that MAR-10 contains strong anti-HIV-1 activity that may be useful in the treatment of patients with HIV-1 infection.

• Authors: S Gollapudi, H A Sharma, S Aggarwal, L D Byers, H E Ensley, S Gupta
• Journal: Biochemical and biophysical research communications (Biochem Biophys Res Commun) Vol. 210 Issue 1 Pg. 145-51 (May 05 1995) ISSN: 0006-291X [Print] United States
• PMID: 7741735 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antiviral Agents
• HIV Core Protein p24
• MAR 10
• Polysaccharides
• Glycoside Hydrolases

Topics

• Antiviral Agents
• Cell Fusion (drug effects)
• Cell Survival (drug effects)
• Glycoside Hydrolases (antagonists & inhibitors)
• HIV Core Protein p24 (metabolism)
• HIV Infections (drug therapy)
• Humans
• In Vitro Techniques
• Lymphocyte Activation (drug effects)
• Plants, Medicinal
• Polysaccharides (pharmacology)
• T-Lymphocytes (microbiology)
• Virus Replication (drug effects)