[Current status of the activity of 5-HT3 receptor antagonists in animal pharmacology].

Abstract

Most tests used for the screening of 5-HT3 receptor antagonists are not completely specific but they give satisfactory results when they are used in battery. In cancer chemotherapy and radiotherapy, 5-HT3 receptor antagonists are very active against acute emesis but delayed and anticipatory vomiting remains difficult to cure. Potential activities of 5-HT3 receptor antagonists as neuroleptics, anxiolytics and agents useful against dependence and cognitive disorders pose some problems in animal psychopharmacology and remain to be clinically validated.

• Authors: G Raynaud
• Journal: Annales pharmaceutiques francaises (Ann Pharm Fr) Vol. 53 Issue 1 Pg. 19-23 ( 1995) ISSN: 0003-4509 [Print] France
• Vernacular Title: Bilan actuel de l'activité des antagonistes des récepteurs 5-HT3 en pharmacologie animale.
• PMID: 7741422 (Publication Type: English Abstract, Journal Article, Review)

Chemical References

• Antiemetics
• Psychotropic Drugs
• Serotonin Antagonists

Topics

• Animals
• Antiemetics
• Cats
• Disease Models, Animal
• Dogs
• In Vitro Techniques
• Psychotropic Drugs
• Rats
• Serotonin Antagonists (pharmacology)