Abstract |
Regulation of macrophage scavenger receptor (MSR) activity may be an important determinant of the extent of atherogenesis and the efficacy of host defense. The effect of M-CSF on this pathway was studied using a recently developed monoclonal antibody to murine MSR. M-CSF markedly and selectively increased MSR synthesis in murine macrophages (M phi); post-translationally the receptor appeared more stable and shifted to a predominantly surface distribution. Functionally M-CSF enhanced modified lipoprotein uptake and increased divalent cation-independent adhesion in vitro. These results suggest a plausible mechanism whereby M-CSF production in the atheromatous plaque microenvironment could promote the recruitment and retention of mononuclear phagocytes and subsequent foam cell formation. In addition, the Th1 cytokine ( gamma-interferon) and Th2 cytokine (interleukin-4) had differential effects on MSR glycosylation in vitro suggesting a further possible regulatory role by these lymphokines on macrophage MSR function.
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Authors | W J de Villiers, I P Fraser, S Gordon |
Journal | Immunology letters
(Immunol Lett)
Vol. 43
Issue 1-2
Pg. 73-9
(Dec 1994)
ISSN: 0165-2478 [Print] Netherlands |
PMID | 7737693
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
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Chemical References |
- Cytokines
- Lipoproteins, LDL
- Receptors, Immunologic
- Receptors, Scavenger
- Macrophage Colony-Stimulating Factor
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Topics |
- Arteriosclerosis
(immunology)
- Cytokines
(physiology)
- Down-Regulation
(physiology)
- Humans
- Lipoproteins, LDL
(metabolism)
- Macrophage Colony-Stimulating Factor
(physiology)
- Receptors, Immunologic
(biosynthesis, physiology)
- Receptors, Scavenger
- Up-Regulation
(physiology)
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