Abstract | BACKGROUND: METHODS: A battery of nine lectins was applied to paraffin sections from 20 prostatectomies to identify prostatic carcinoma. The patterns of lectin binding were compared among normal/hyperplastic, dysplastic, and malignant glands. The increase in the Ki-67-defined growth fraction was compared with the lectin binding pattern. RESULTS: CONCLUSIONS: These findings suggest that the early dysplastic lesions in the prostate may be part of a continuum in the multistep process leading to invasive carcinoma.
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Authors | C B Drachenberg, J C Papadimitriou |
Journal | Cancer
(Cancer)
Vol. 75
Issue 10
Pg. 2539-44
(May 15 1995)
ISSN: 0008-543X [Print] United States |
PMID | 7736399
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Arthropod Proteins
- Ki-67 Antigen
- Lectins
- Neoplasm Proteins
- Nuclear Proteins
- Peanut Agglutinin
- Plant Lectins
- Soybean Proteins
- Ulex europaeus lectins
- Wheat Germ Agglutinins
- soybean lectin
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Topics |
- Adenocarcinoma
(metabolism)
- Arachis
- Arthropod Proteins
- Carcinoma
(metabolism)
- Humans
- Hyperplasia
- Ki-67 Antigen
- Lectins
(metabolism)
- Male
- Neoplasm Invasiveness
- Neoplasm Proteins
(metabolism)
- Nuclear Proteins
(metabolism)
- Peanut Agglutinin
- Plant Lectins
- Precancerous Conditions
(metabolism)
- Prostatic Neoplasms
(metabolism)
- Protein Binding
- Soybean Proteins
- Soybeans
- Wheat Germ Agglutinins
(metabolism)
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