Abstract | BACKGROUND: METHODS: EIU was produced in rats by hind foot-pad injection of LPS (100 micrograms/animal). Animals were killed 20 h after LPS injection. Inflammation was evaluated by anterior chamber determination of proteins and cells. RESULTS: A dosage of 400 mg/kg per day of thalidomide was efficient in reducing inflammation whether given in three doses (at -24 h, -4 h and +4 h relative to LPS challenge = THAL-1; p < 0.001 for proteins and cells), in two doses (-4 h and +4 h = THAL-2; p < 0.001 for proteins, p < or = 0.012 for cells) or in one dose (at +4 h = late THAL; p < 0.001 for proteins, p < or = 0.02 for cells). A dosage of 300 mg/kg per day of thalidomide was still efficient (p < or = 0.023 for proteins, p < or = 0.06 for cells), but 150 mg/kg per day had no effect on inflammation. Supidimide (400 mg/kg per day) had some anti-inflammatory effect (p < or = 0.053 for proteins, p < or = 0.06 for cells). CONCLUSION: High-dose thalidomide had a potent anti-inflammatory effect in EIU, but lower doses were not sufficient to reduce inflammation. At similar high doses, supidimide had some effect on EIU but was less effective than thalidomide.
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Authors | Y Guex-Crosier, N Pittet, C P Herbort |
Journal | Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie
(Graefes Arch Clin Exp Ophthalmol)
Vol. 233
Issue 2
Pg. 90-3
(Feb 1995)
ISSN: 0721-832X [Print] Germany |
PMID | 7729710
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Bacterial Toxins
- Endotoxins
- Enterotoxins
- salmonella toxin
- Thalidomide
- supidimide
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Topics |
- Acute Disease
- Animals
- Anterior Chamber
(pathology)
- Aqueous Humor
- Bacterial Toxins
- Endotoxins
- Enterotoxins
- Injections, Intraperitoneal
- Male
- Rats
- Rats, Inbred Lew
- Thalidomide
(administration & dosage, analogs & derivatives, therapeutic use)
- Uveitis, Anterior
(chemically induced, drug therapy, prevention & control)
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