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Effect of fluoxetine on melatonin in patients with seasonal affective disorder and matched controls.

AbstractBACKGROUND:
The aim was to investigate the secretion profile of melatonin and seasonal affective disorder before and after treatment with fluoxetine.
METHOD:
A six-week case-controlled study with repeated overnight blood sampling was conducted. Ten patients fulfilling the criteria for major depressive disorder, seasonal type, with a 29-item Hamilton Depression Rating Scale (HDRS) score of at least 20 were compared with ten age- and sex-matched healthy controls in a clinical laboratory. The effects of fluoxetine (20 mg/day) on the HDRS and melatonin concentration were measured.
RESULTS:
Fluoxetine significantly reduced melatonin levels in both groups. There was no significant difference in melatonin secretion between the groups.
CONCLUSIONS:
The effect of fluoxetine differs from tricyclics and fluvoxamine, both of which increase melatonin.
AuthorsP A Childs, I Rodin, N J Martin, N H Allen, L Plaskett, P J Smythe, C Thompson
JournalThe British journal of psychiatry : the journal of mental science (Br J Psychiatry) Vol. 166 Issue 2 Pg. 196-8 (Feb 1995) ISSN: 0007-1250 [Print] England
PMID7728363 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Receptors, Adrenergic, beta-1
  • Fluoxetine
  • Melatonin
Topics
  • Adult
  • Female
  • Fluoxetine (pharmacology, therapeutic use)
  • Humans
  • Hypothalamus (drug effects)
  • Male
  • Melatonin (metabolism)
  • Receptors, Adrenergic, beta-1 (drug effects)
  • Seasonal Affective Disorder (drug therapy)
  • Treatment Outcome

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