Some analogues of 1,4-disubstituted piperazines as hypnotic and sedative agents.

Abstract	Preparation, analytical data, and biological properties such as acute toxicity, influence on spontaneous and amphetamine induced locomotor activity, hypnotic activity, influence on hexobarbital narcosis and anticonvulsant activity of new analogues of pyrimidyl piperazines--ethyl 3-[4-(2-pyrimidyl)-1-piperazinyl]-3-oxopropanoate (4), 1-[4-(2-pyrimidyl)-1-piperazinyl]-1,3-butandione (5), ethyl 3-[4-(2-pyrimidyl)-1-piperazinyl]butanoate (6) and 1-[4-(2-pyrimidyl)-1-piperazinyl]-2-acetyl-1-hexanone (7)--are reported.
Authors	Z Chilmonczyk, M Bogdal, A Zaworska, J Cybulski, W Szelejewski
Journal	Archiv der Pharmazie (Arch Pharm (Weinheim)) Vol. 328 Issue 2 Pg. 187-91 (Feb 1995) ISSN: 0365-6233 [Print] Germany
PMID	7726746 (Publication Type: Journal Article)
Chemical References	Anticonvulsants Hypnotics and Sedatives Piperazines Amphetamine
Topics	Amphetamine (antagonists & inhibitors, pharmacology) Animals Anticonvulsants (pharmacology) Hypnotics and Sedatives (chemical synthesis, pharmacology, toxicity) Mice Motor Activity (drug effects) Piperazines (chemical synthesis, pharmacology, toxicity)

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