Abstract |
Nonspecific X-linked mental retardation (MRX) includes several distinct genetic entities in which mental retardation is not associated with additional distinguishing physical changes. We report linkage data in a Spanish family with MRX, using polymorphic DNA markers distributed over the X chromosome. Two-point linkage analysis demonstrated close linkage between the MRX locus and DXS85 in Xp22.3 with a peak lod score of 2.28 at a theta = 0.00. Analysis of multiple informative meioses suggested a localization of the MRX locus (MRX24) between DXS278 and DXS207. Multipoint linkage analysis resulted in a maximum LOD score of 2.45 at 3 cM proximal to DXS85, and allowed us to reject a localization of the MRX24 gene in all other regions from Xp21-Xqter. These findings localize the MRX24 gene in the chromosomal region Xp22.2-p22.3.
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Authors | F Martínez, A Gal, F Palau, F Prieto |
Journal | American journal of medical genetics
(Am J Med Genet)
Vol. 55
Issue 3
Pg. 387-90
(Jan 30 1995)
ISSN: 0148-7299 [Print] United States |
PMID | 7726242
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Topics |
- Chromosome Mapping
- Female
- Genetic Linkage
- Humans
- Infant
- Intellectual Disability
(genetics)
- Male
- Pedigree
- X Chromosome
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