Abstract | BACKGROUND: Benign cystic mesothelioma, a tumor characteristically found in women during the reproductive years, is rare after bilateral oophorectomy or menopause, suggesting hormonal sensitivity. CASE: We treated a 17-year-old woman with a rapidly increasing and symptomatic benign cystic mesothelioma with a long-acting GnRH agonist. A rapid and continued reduction in volume corresponded to the induction and maintenance of a hypoestrogenic state over a 6-month period. However, the subsequent addition of a combination of estrogen and progestin (known as add-back therapy) resulted in a gradual increase in cyst volume, which progressed after discontinuation of all therapy. Resumption of GnRH-analog therapy alone reduced cyst volume again, and the patient underwent surgical removal. CONCLUSION: Long-acting GnRH agonists may have a role in the conservative management of these rare neoplasms. The reduction in volume concomitant with a hypoestrogenic state and regrowth with addition of add-back therapy further suggest extreme sensitivity of this tumor to one or both hormones.
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Authors | G S Letterie, J L Yon |
Journal | Obstetrics and gynecology
(Obstet Gynecol)
Vol. 85
Issue 5 Pt 2
Pg. 901-3
(May 1995)
ISSN: 0029-7844 [Print] United States |
PMID | 7724156
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Delayed-Action Preparations
- Progestins
- Gonadotropin-Releasing Hormone
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Topics |
- Adolescent
- Delayed-Action Preparations
- Estrogen Replacement Therapy
- Female
- Gonadotropin-Releasing Hormone
(administration & dosage, analogs & derivatives)
- Humans
- Mesothelioma, Cystic
(drug therapy, surgery)
- Pelvic Neoplasms
(drug therapy, surgery)
- Peritoneal Neoplasms
(drug therapy, surgery)
- Progestins
(therapeutic use)
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