Enhancing effect of DQ-2511 on gastric emptying of spontaneously hypertensive rats.

Abstract

The present study was designed to clarify the potential of DQ-2511 (3-[[[2-(3,4-dimethoxyphenyl)ethyl]carbamoyl]carbamoyl]methyl] amino-N-methylbenzamide: ecabapide) as a gastroprokinetic agent in spontaneously hypertensive rats (SHR). The gastric emptying of SHR was clearly retarded relative to that of weight-matched normotensive Wistar-Kyoto (WKY) rats when evaluated by the acetaminophen (APAP) method with the semi-solid test meal. There was, however, no significant difference between both strains in gastric mucosal blood flow (GMBF) determined by means of a laser doppler flowmetry. A 2-week treatment of SHR with DQ-2511 (1 mg/kg, oral) stimulated gastric emptying without affecting body weight gain or indirect systolic blood pressure (SBP), whereas cisapride (3 and 10 mg/kg, oral) had no effect under the same conditions. The pharmacological characteristics of DQ-2511 as a gastroprokinetic agent are discussed on the basis of these results.

• Authors: S Hatanaka, K Kawarabayashi, M Iseri, K Tsubokura, K Furuhama
• Journal: Life sciences (Life Sci) Vol. 56 Issue 19 Pg. PL377-82 ( 1995) ISSN: 0024-3205 [Print] Netherlands
• PMID: 7723581 (Publication Type: Journal Article)

Chemical References

• Anti-Ulcer Agents
• Benzamides
• Vasopressins
• ecabapide

Topics

• Animals
• Anti-Ulcer Agents (pharmacology)
• Benzamides (pharmacology)
• Gastric Emptying (drug effects)
• Hypertension (physiopathology)
• Male
• Rats
• Rats, Inbred SHR
• Rats, Inbred WKY
• Vasopressins (blood)