Transforming growth factor-beta: possible roles in Dupuytren's contracture.

Abstract

Transforming growth factor-beta (TGF-beta) is a multifunctional polypeptide that stimulates extracellular matrix deposition and fibroblast proliferation. Because both these features characterize Dupuytren's contracture, we investigated a possible role for TGF-beta in the etiology of this disorder. We studied receptor expression for TGF-beta, effects of TGF-beta 1 on DNA-synthesis, and in vitro production of TGF-beta 1 and TGF-beta 2 in both normal and Dupuytren-derived fibroblasts. We also studied the effects of epidermal growth factor (EGF) on growth of the different cell types. TGF-beta receptor profiles were different between the two cell types, as were TGF-beta 1 and EGF-induced stimulation of cell growth. Both cell types secreted both active and latent TGF-beta. Our results suggest that growth factors such as TGF-beta and EGF may play a role in Dupuytren's contracture.

• Authors: P Kloen, C L Jennings, M C Gebhardt, D S Springfield, H J Mankin
• Journal: The Journal of hand surgery (J Hand Surg Am) Vol. 20 Issue 1 Pg. 101-8 (Jan 1995) ISSN: 0363-5023 [Print] United States
• PMID: 7722248 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Receptors, Transforming Growth Factor beta
• Transforming Growth Factor beta
• Epidermal Growth Factor
• DNA

Topics

• Adult
• Aged
• Animals
• Cells, Cultured (chemistry)
• DNA (biosynthesis)
• Dupuytren Contracture (genetics, metabolism)
• Epidermal Growth Factor (metabolism)
• Female
• Fibroblasts (chemistry, metabolism)
• Humans
• Male
• Middle Aged
• Mink
• Receptors, Transforming Growth Factor beta (chemistry, metabolism)
• Swine
• Transforming Growth Factor beta (biosynthesis, chemistry, metabolism)