Abstract | BACKGROUND: For accurate classification of cutaneous metastatic carcinoma, reliable tumor-specific immunohistochemical markers would be valuable. OBJECTIVE: Our purpose was to analyze the sensitivity, specificity, and positive predictive value of gross cystic disease fluid protein-15 (GCDFP-15) and estrogen receptor protein (ERP) for diagnosing cutaneous metastatic breast carcinoma. METHODS: Tissue sections from 68 consecutive cases of cutaneous metastatic carcinoma were stained for GCDFP-15 and ERP. Hematoxylin- eosin-stained slides and immunostained slides were reviewed in a blinded fashion before retrospective chart review to ascertain the underlying primary tumor type. RESULTS: Of 42 cases of cutaneous metastatic breast carcinoma, 30 were positive for GCDFP-15. Of 41 cases of metastatic breast carcinoma, 30 were positive for ERP. Calculated sensitivity, specificity, and positive predictive value for GCDFP-15 for diagnosing cutaneous metastatic breast carcinoma were 71%, 91%, and 94%, respectively, and 73%, 100%, and 100% for ERP, respectively. Combined values of these indices for both stains were 83%, 91%, and 95%, respectively. CONCLUSION: GCDFP-15 and ERP are valuable markers for cutaneous metastatic breast carcinoma and should be used in combination.
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Authors | A H Ormsby, J L Snow, W P Su, J R Goellner |
Journal | Journal of the American Academy of Dermatology
(J Am Acad Dermatol)
Vol. 32
Issue 5 Pt 1
Pg. 711-6
(May 1995)
ISSN: 0190-9622 [Print] United States |
PMID | 7722013
(Publication Type: Journal Article)
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Chemical References |
- APOD protein, human
- Apolipoproteins
- Apolipoproteins D
- Biomarkers, Tumor
- Carrier Proteins
- Glycoproteins
- Membrane Transport Proteins
- PIP protein, human
- Receptors, Estrogen
- estrophilin
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Topics |
- Apolipoproteins
- Apolipoproteins D
- Biomarkers, Tumor
(analysis)
- Breast Neoplasms
(pathology)
- Carrier Proteins
(analysis)
- Female
- Glycoproteins
- Humans
- Immunohistochemistry
- Membrane Transport Proteins
- Predictive Value of Tests
- Receptors, Estrogen
(analysis)
- Sensitivity and Specificity
- Skin Neoplasms
(chemistry, diagnosis, secondary)
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