The effects of
IGN-2098 on the healing process of
acetic acid-induced
gastric ulcer was investigated in comparison with the other
histamine H2-receptor antagonists,
famotidine and
roxatidine acetate HCl, in rats.
Ulcer was induced by the injection of
acetic acid solution (20%, 0.05 ml). From the 4th day to 17th day after the
ulcer induction, drugs were orally administered twice a day. On the 18th day after the
ulcer induction, rats were sacrificed to measure the
ulcer index macroscopically and to take pictures of the stomachs. Judging from the photographs, the prominence of
ulcer the edge was graded into 4 classes, which showed a significant correlation with the histological amount of connective tissue at the
ulcer edge. All drugs accelerated the healing of the
ulcer, and the effect of
IGN-2098 was the most remarkable. In addition, IGN-2098-treatment exhibited more marked inhibition against the prominence of the
ulcer edge as compared with the control group. Based on these results, it is concluded that
IGN-2098 may be a useful
drug for the clinical treatment of
ulcer and that the healing acceleration by
IGN-2098 without prominence of the
ulcer edge may induce no relapse of the
ulcer after healing.