[Investigation on etiology of abnormal ratio of CD4/CD8 cells in allergic nasal mucosal epithelium].

The lymphocytes of nasal mucosal epithelium were separated and the phenotype number of CD3, CD4 and CD8 cells were identified with immunohistochemical staining under light microscope. The number was increased significantly in CD4 cells and decreased in CD8 cells of rats' nasal epithelium after stimulation with histamine. Abnormal ratio of CD4 and CD3 cells in the allergic nasal epithelium tended to be normal after treatment with H2 antagonist. The results of our investigation demonstrated that histamine might cause the number of CD4 and CD8 cells into disorder in allergic nasal mucosal epithelium and the H2 antagonist may be useful in the treatment of allergic rhinitis.
AuthorsP Yang
JournalZhonghua er bi yan hou ke za zhi (Zhonghua Er Bi Yan Hou Ke Za Zhi) Vol. 29 Issue 5 Pg. 286-8 ( 1994) ISSN: 0412-3948 [Print] CHINA
PMID7718292 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Cimetidine
  • Adolescent
  • Adult
  • Animals
  • CD4-CD8 Ratio (drug effects)
  • Cimetidine (therapeutic use)
  • Epithelium (immunology)
  • Female
  • Humans
  • Male
  • Nasal Mucosa (immunology)
  • Rats
  • Rats, Wistar
  • Rhinitis, Allergic, Perennial (drug therapy, immunology)

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