HLA-DR8 and acute anterior uveitis in ankylosing spondylitis.

Abstract

OBJECTIVE:

To identify possible factors in the development of acute anterior uveitis (AUU) in patients with ankylosing spondylitis (AS).

METHODS:

We investigated HLA antigens serologically, and HLA-DRB1*08 alleles by polymerase chain reaction-restriction fragment length polymorphism, in 42 Japanese AS patients with and without AAU.

RESULTS:

Thirty-six of the AS patients (85.7%) had HLA-B27. Thirteen (65%) of the 20 patients with AAU had HLA-DR8, whereas only 1 (4.5%) of the 22 patients without AAU had DR8. The difference was statistically significant (Pcorr < 0.001).

CONCLUSION:

Our data suggest that HLA-B27 is strongly associated with AS in Japanese patients and that HLA-DR8 is important for the development of AAU in Japanese patients with AS.

• Authors: S M Monowarul Islam, J Numaga, Y Fujino, K Masuda, H Ohda, R Hirata, H Maeda, H Mitsui
• Journal: Arthritis and rheumatism (Arthritis Rheum) Vol. 38 Issue 4 Pg. 547-50 (Apr 1995) ISSN: 0004-3591 [Print] United States
• PMID: 7718009 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• HLA Antigens
• HLA-B27 Antigen
• HLA-DR Antigens
• HLA-DR Serological Subtypes
• HLA-DR8 antigen
• Molecular Probes

Topics

• Acute Disease
• Adult
• Asian People
• Base Sequence
• Female
• HLA Antigens (analysis, classification)
• HLA-B27 Antigen (analysis)
• HLA-DR Antigens (analysis)
• HLA-DR Serological Subtypes
• Humans
• Male
• Molecular Probes (genetics)
• Molecular Sequence Data
• Reference Values
• Spondylitis, Ankylosing (complications, immunology)
• Uveitis, Anterior (complications, immunology)