[Effects of furyl-dihydropyridine I on coronary collateral circulation in myocardial infarction of dogs].

Abstract

Effects of furyl-dihydropyridine I (FDP-1) on collateral circulation were observed in ischemic myocardium of dogs. FDP-1 (200 micrograms.kg-1) of intracoronary injection increased collateral flow, reduced systemic artery resistance, and coronary systolic pressure in infarcted region and the area of infarction decreased from 28.9 +/- 1.3% to 15.3 +/- 1.2% (P < 0.01, n = 6). The results indicated that FDP-1 could improve coronary collateral circulation, increase collateral flow in ischemic region, decrease collateral flow in ischemic region, decrease myocardial oxygen demand, and protect myocardial ischemia.

• Authors: M J Jia, S L Chen, Y L Liao, D Q Liu, L S Li, N P Zhao
• Journal: Zhongguo yao li xue bao = Acta pharmacologica Sinica (Zhongguo Yao Li Xue Bao) Vol. 15 Issue 5 Pg. 462-5 (Sep 1994) ISSN: 0253-9756 [Print] China
• PMID: 7717077 (Publication Type: English Abstract, Journal Article)

Chemical References

• Calcium Channel Blockers
• Dihydropyridines
• 2,6-dimethyl-4-furyl-1,4-dihydropyridine-5-dicarboxylate

Topics

• Animals
• Calcium Channel Blockers (pharmacology)
• Collateral Circulation (drug effects)
• Coronary Circulation (drug effects)
• Dihydropyridines (pharmacology)
• Dogs
• Female
• Male
• Myocardial Infarction (pathology, physiopathology)
• Myocardium (pathology)