[Study of the anti-HIV activity of miramistin].

Abstract

The anti-HIV activity of a cationic detergent myramistin and nonionic detergent dezintegron-0 (d-0) was studied using HIV-1 strains III B/H9 and BRU in lymphoblastoid cells MT-4 and Jurkat-tat. Myramistin in a concentration of 0.075 mg/ml was shown to prevent HIV-1 replication in MT-4 when these cells were cocultivated with the cells preinfected and treated with the detergent. Myramistin in concentrations from 0.030 to 0.050 mg/ml delayed the accumulation of virus antigens in the cells by 4 and 14 days, respectively, without preventing the infection of intact cells. Nonionic d-0 prevented HIV-1 infection of intact Jurkat-tat cells at a concentration of 12.5 mg/ml.

• Authors: Iu L Krivorutchenko, KrivosheinIuS, S S Marennikova, L G Stepanova, D N Nosik, L B Kalnina, A P Rud'ko
• Journal: Voprosy virusologii (Vopr Virusol) 1994 Nov-Dec Vol. 39 Issue 6 Pg. 267-9 ISSN: 0507-4088 [Print] Russia (Federation)
• Vernacular Title: Izuchenie anti-VICh-aktivnosti miramistina.
• PMID: 7716921 (Publication Type: Journal Article)

Chemical References

• Antiviral Agents
• Benzalkonium Compounds
• Cyclic N-Oxides
• Detergents
• desintegron O
• miramistin

Topics

• Antiviral Agents (pharmacology)
• Benzalkonium Compounds (pharmacology)
• Cell Line
• Cyclic N-Oxides (pharmacology)
• Detergents (pharmacology)
• Dose-Response Relationship, Drug
• HIV-1 (drug effects, physiology)
• Humans
• Virus Replication (drug effects)