Urinary excretion of galactosyl-hydroxylysine is a marker of growth in children.

Abstract

Galactosyl-hydroxylysine (Gal-Hyl) is the predominant product of the posttranslational glycosylation of skeletal collagen. Urinary Gal-Hyl excretion is regarded as a marker of bone resorption in adults, but little information is available on the validity of this parameter in pediatric age groups. Using 24-h urine samples from 88 healthy children and adolescents ages 4-18 yr, reference ranges were established for this age group, and values were compared with measurements in children with overt GH deficiency (n = 14) or Ullrich-Turner syndrome (n = 21). When expressed relative to body weight (Gal-Hyl/wt), urinary Gal-Hyl excretion was 3.2 to 4.7 times higher in subjects 4-16 yr of age than in adults. Highest values were observed in very young children and during the pubertal growth spurt. In the total population, urinary Gal-Hyl/wt was closely related to growth velocity (r = 0.72) and significantly correlated with the urinary excretion of both hydroxyproline (r = 0.74) and deoxypyridinoline (r = 0.88; P < 0.001 each). Urinary Gal-Hyl/wt was significantly lower in children with GH deficiency or Ullrich-Turner syndrome than in healthy children (P < 0.001 each). The urinary excretion of Gal-Hyl was significantly correlated with growth velocity in GH-deficient children (r = 0.69; P = 0.004) but not in patients with Ullrich-Turner syndrome. In the latter, the increase in urinary Gal-Hyl excretion after 3 months of treatment with recombinant human GH correlated significantly with the increase in growth velocity after 12 months of treatment (r = 0.76; P = 0.002). We conclude that the urinary excretion of Gal-Hyl is a valid and potentially useful index of skeletal growth in children.

• Authors: F Rauch, D Schnabel, M J Seibel, T Remer, A Stabrey, D Michalk, E Schönau
• Journal: The Journal of clinical endocrinology and metabolism (J Clin Endocrinol Metab) Vol. 80 Issue 4 Pg. 1295-300 (Apr 1995) ISSN: 0021-972X [Print] United States
• PMID: 7714103 (Publication Type: Journal Article)

Chemical References

• Amino Acids
• Biomarkers
• Recombinant Proteins
• Hydroxylysine
• galactosylhydroxylysine
• Growth Hormone
• deoxypyridinoline
• Hydroxyproline

Topics

• Adolescent
• Adult
• Aging (urine)
• Amino Acids (urine)
• Biomarkers
• Bone Resorption (urine)
• Child
• Child Development
• Child, Preschool
• Female
• Growth Disorders (drug therapy, urine)
• Growth Hormone (therapeutic use, urine)
• Humans
• Hydroxylysine (analogs & derivatives, urine)
• Hydroxyproline (urine)
• Male
• Recombinant Proteins
• Reference Values