HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

The contribution of delta 1- and delta 2-opioid receptors to hypoxia-induced pial artery dilation in the newborn pig.

Abstract
Previously, it has been observed that mu-opioid receptors contribute to while kappa-opioid receptors oppose pial artery dilation in response to hypoxia. The present study was designed to investigate the contribution of delta 1- and delta 2-opioid receptor activation to hypoxia-induced pial vasodilation. Newborn pigs equipped with a closed cranial window were used to measure pial artery diameter and collect cortical periarachnoid CSF for assay of opioids. Hypoxia increased CSF leucine enkephalin (a delta -agonist) from 36 +/- 6 to 113 +/- 17 pg/ml (n = 5). Hypoxia-induced pial artery vasodilation was attenuated during moderate hypoxia (PaO2 approximately 35 mm Hg), while this response was blunted during severe hypoxia (PaO2 approximately 25 mm Hg), by the delta 1-opioid receptor antagonist 7-benzylidenenaltrexone (BNTX; 10(-8) M) (23 +/- 2 vs. 13 +/- 2 and 34 +/- 6 vs. 10 +/- 3% for moderate and severe hypoxia in the absence and presence of BNTX, respectively; n = 5). In contrast, the delta 2-opioid receptor antagonist naltrindole (10(-9) M) blunted pial vasodilation during moderate hypoxia, but only attenuated the vasodilator response during severe hypoxia (22 +/- 2 vs. 8 +/- 2 and 33 +/- 4 vs. 23 +/- 4% for moderate and severe hypoxia in the absence and presence of naltrindole, respectively; n = 5).(ABSTRACT TRUNCATED AT 250 WORDS)
AuthorsW M Armstead
JournalJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (J Cereb Blood Flow Metab) Vol. 15 Issue 3 Pg. 539-46 (May 1995) ISSN: 0271-678X [Print] United States
PMID7714013 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Benzylidene Compounds
  • Enkephalins
  • Narcotic Antagonists
  • Oligopeptides
  • Receptors, Opioid, delta
  • Receptors, Opioid, mu
  • deltorphin II, Ala(2)-
  • 7-benzylidenenaltrexone
  • Naltrexone
  • Enkephalin, D-Penicillamine (2,5)-
Topics
  • Animals
  • Animals, Newborn
  • Benzylidene Compounds (pharmacology)
  • Enkephalin, D-Penicillamine (2,5)-
  • Enkephalins (pharmacology)
  • Female
  • Hypoxia (metabolism)
  • Male
  • Naltrexone (analogs & derivatives, pharmacology)
  • Narcotic Antagonists (pharmacology)
  • Oligopeptides (pharmacology)
  • Pia Mater (blood supply)
  • Receptors, Opioid, delta (agonists)
  • Receptors, Opioid, mu (antagonists & inhibitors, metabolism)
  • Swine
  • Vasodilation

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: