Abstract |
1. The premorbid behaviors produced by the administration of cocaine, ethanol, their combination, as well as a metabolite produced by their co-administration, viz. cocaethylene, were defined, determined and quantified in the HS strain of mice. 2. The LD50 for ethanol was 9.71 g/kg in males and 9.45 g/kg in females, whereas the LD50 values in male and female mice for cocaine were 101.55 and 90.00 mg/kg, respectively. 3. The data indicate that clonic- tonic seizures continued into status epilepticus after cocaine administration and prior to cocaine-induced lethality. In contrast, administration of the cocaine- ethanol metabolite cocaethylene produced status epilepticus without producing clonic- tonic seizures yet still resulted in lethality. 4. Thus, both cocaine and cocaethylene may produce their lethal effects in mice through neuro-regulatory mechanisms mediating protracted seizure induction.
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Authors | S M Meehan, M D Schechter |
Journal | General pharmacology
(Gen Pharmacol)
Vol. 26
Issue 1
Pg. 99-106
(Jan 1995)
ISSN: 0306-3623 [Print] England |
PMID | 7713372
(Publication Type: Journal Article)
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Chemical References |
- Ethanol
- cocaethylene
- Cocaine
|
Topics |
- Animals
- Behavior, Animal
(drug effects)
- Cocaine
(analogs & derivatives, toxicity)
- Dose-Response Relationship, Drug
- Ethanol
(toxicity)
- Female
- Lethal Dose 50
- Male
- Mice
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