[Expression of human chorionic gonadotropin, human placental lactogen and pregnancy-specific 1-glycoprotein in malignant trophoblastic neoplasms].

Abstract

The expression of placental hormones in 91 malignant trophoblastic neoplasms was studied immunohistochemically using a panel of antibodies against hCG, human placental lactogen (hPL) and pregnancy-specific 1-glycoprotein (SP). The results indicated that the expression of hCG in invasive moles was weaker than that in choriocarcinoma, but the expression of hPL and SP1 was stronger than those in choriocarcinoma. The expression of hPL and SP1 in the metastatic tumors of invasive moles was weaker than the expression at in the primary tumors, but the secretory capacity of hCG in metastatic choriocarcinomas was stronger than that in the primary neoplasms. In this study, the qualities of expression of the placental hormones in invasive moles and choriocarcinomas corresponded to the degree of tumor malignancy, the biological behaviour and the grading of trophoblastic cell differentiation. We believe that the detection of hCG, hPL and SP1, in malignant trophoblastic neoplasms was of value for establishing tumor diagnosis and typing and for judgement on prognosis.

• Authors: Y Y Xiong, J Zeng, Z J Tang
• Journal: Zhonghua fu chan ke za zhi (Zhonghua Fu Chan Ke Za Zhi) Vol. 29 Issue 10 Pg. 610-3, 638 (Oct 1994) ISSN: 0529-567X [Print] China
• PMID: 7712876 (Publication Type: English Abstract, Journal Article)

Chemical References

• Biomarkers, Tumor
• Chorionic Gonadotropin
• Pregnancy-Specific beta 1-Glycoproteins
• Placental Lactogen

Topics

• Biomarkers, Tumor (analysis)
• Choriocarcinoma (chemistry, secondary)
• Chorionic Gonadotropin (analysis)
• Female
• Humans
• Hydatidiform Mole, Invasive (chemistry)
• Placental Lactogen (analysis)
• Pregnancy
• Pregnancy-Specific beta 1-Glycoproteins (analysis)
• Uterine Neoplasms (chemistry)
• Vaginal Neoplasms (chemistry, secondary)