Labeling and quantitative analysis of six lectin receptors of intracranial gliomas.

Abstract

The distribution of six lectin receptors, WGA, RCA-1, LCA, PSA, PNA and SBA in 111 human gliomas, 8 human normal brain tissues and 11 reactive hyperplasia of astrocytes was observed by means of avidin-biotin-peroxidase technique. Their grays were also quantified with the image analysis instrument. The results showed that WGA and RCA-1 might be used as markers for distinguishing well-differentiated astrocytomas from the reactive hyperplasia of astrocytes especially the reactivity of astrocytes had a specific feature with RCA-1. The difference in quantities of WGA, RCA-1, LCA, PSA receptors between astrocytomas, ependymomas and oligodendrogliomas, medulloblastomas might conduce to the diagnosis and classification. For astrocytomas, it was also showed that a quantity of LCA and PSA receptors was correlated with the degree of cell differentiation. Therefore, they can be used as valuable markers of the differentiation of astrocytomas.

• Authors: S Yang, Z Liu, Y Zhu, X Chen
• Journal: Chinese medical journal (Chin Med J (Engl)) Vol. 108 Issue 1 Pg. 37-43 (Jan 1995) ISSN: 0366-6999 [Print] China
• PMID: 7712837 (Publication Type: Journal Article)

Chemical References

• Biomarkers, Tumor
• Plant Proteins
• Receptors, Mitogen
• Ricinus communis lectin receptor
• Wheat Germ Agglutinins
• wheat germ agglutinin receptor

Topics

• Astrocytoma (chemistry)
• Biomarkers, Tumor (analysis)
• Brain Neoplasms (chemistry)
• Glioblastoma (chemistry)
• Humans
• Image Processing, Computer-Assisted
• Plant Proteins (analysis)
• Receptors, Mitogen (analysis)
• Wheat Germ Agglutinins (analysis)