The genotoxicity of substituted nitrobenzenes and the quantitative structure-activity relationship studies.

Abstract

The genotoxicity of 22 substituted nitrobenzenes was evaluated by the chromosome aberrations test in cultured human peripheral lymphocytes. 18 of 22 compounds exhibit genotoxic activities. A quantitative structure-activity relationship model was established to correlate the genotoxicity of substituted nitrobenzenes and the characteristics of the substituents on the benzene ring.

• Authors: Q Huang, L Wang, S Han
• Journal: Chemosphere (Chemosphere) Vol. 30 Issue 5 Pg. 915-23 (Mar 1995) ISSN: 0045-6535 [Print] England
• PMID: 7712138 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Nitrobenzenes

Topics

• Cell Count (drug effects)
• Cells, Cultured
• Chromosome Aberrations (genetics)
• Humans
• Lymphocytes (cytology, drug effects)
• Male
• Mutation (drug effects, genetics)
• Nitrobenzenes (chemistry, toxicity)
• Occupational Exposure
• Regression Analysis
• Structure-Activity Relationship