Abstract |
Human immunodeficiency virus (HIV) primary isolates, derived from donors at various stages of HIV infection, were assayed for their sensitivity to interferon ( IFN)-alpha 2 in vitro. These isolates displayed a broad range of sensitivity to IFN-alpha 2. The prevalence of IFN-alpha 2 resistance was low in the absence of AIDS but dramatically increased once HIV infection progressed to AIDS. Although there was no linear correlation between the percentage of IFN-alpha 2 inhibition in vitro and the CD4 cell number in vivo or the level of endogenous IFN-alpha, serum IFN-alpha levels were higher in donors with AIDS and were associated with low CD4 cell numbers. Thus, circulating IFN-alpha appeared to either promote resistance or favor survival of IFN-alpha resistant variants. IFN-alpha 2 resistance was neither limited to a particular cell tropism nor enhanced by therapy with zidovudine. Sequential analysis indicated that reversion to IFN-alpha 2 sensitivity could occur during the course of infection.
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Authors | M S Künzi, H Farzadegan, J B Margolick, D Vlahov, P M Pitha |
Journal | The Journal of infectious diseases
(J Infect Dis)
Vol. 171
Issue 4
Pg. 822-8
(Apr 1995)
ISSN: 0022-1899 [Print] United States |
PMID | 7706808
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Interferon Type I
- Interferon-alpha
- Recombinant Proteins
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Topics |
- Acquired Immunodeficiency Syndrome
(immunology, virology)
- CD4 Lymphocyte Count
- Cohort Studies
- Disease Progression
- Drug Resistance, Microbial
- Female
- HIV Infections
(immunology, virology)
- HIV-1
(drug effects, physiology)
- Humans
- Interferon Type I
(pharmacology)
- Interferon-alpha
(blood)
- Leukocytes, Mononuclear
(virology)
- Macrophages
(virology)
- Male
- Recombinant Proteins
- Virus Replication
(drug effects)
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