[Therapeutic alternatives in complicated nonsurgical pulmonary aspergillomas]

• Abstract: We present 2 patients with pulmonary aspergilloma complicated by massive hemoptysis who were not good candidates for surgery and were treated with intracavitary amphotericin B after arterial embolization failed. In spite of the size of the mycetomas, response to treatment was excellent with full regression of the aspergilloma after 3 to 4 weeks; precipitins to Aspergillus fumigatus became negative and the fungus disappeared from transcatheter aspirate samples. Massive hemoptysis was controlled with epsilon-amino-caproic acid instilled by catheter. No complications were observed, the treatment was well tolerated and no recurrence occurred over a follow-up period of 24 and 18 months, respectively. This local treatment is the best therapeutic alternative for patients with pulmonary aspergilloma who are not candidates for surgery.
• Authors: J Ortiz de Saracho, E Pérez-Rodríguez, J Zapatero, J Sánchez, P Navío, J Flores (Affiliation: Servicio de Neumología, Hospital Ramón y Cajal, Madrid.)
• Journal: Archivos de bronconeumología (Arch Bronconeumol) Vol. 31 Issue 2 Pg. 83-5 (Feb 1995) ISSN: 0300-2896 [Print] SPAIN
• Vernacular Title: Alternativa terapéutica para los aspergilomas pulmonares complicados no quirúrgicos.
• PMID: 7704395 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Amphotericin B
• 6-Aminocaproic Acid

Topics

• 6-Aminocaproic Acid (administration & dosage)
• Amphotericin B (administration & dosage, therapeutic use)
• Aspergillosis (complications, drug therapy, radiography)
• Catheterization
• Drug Tolerance
• Follow-Up Studies
• Hemoptysis (drug therapy, etiology)
• Humans
• Lung Diseases, Fungal (complications, drug therapy, radiography)
• Male
• Middle Aged
• Time Factors