Melanogenesis as a targeting strategy against metastatic melanoma: a reassessment.

Abstract

Following the early study of Hochstein and Cohen in 1963 suggesting the potential toxicity of quinonoid melanin precursors, considerable interest has been focused on the possibility of exploiting the pigment-producing pathway as a targeting strategy against metastatic melanoma. Several melanocytotoxic phenolic pro-drugs have been developed, and some of them have reached the preclinical stage. Here we review the progress made so far and supply some insight into the chemical and biochemical mechanisms underlying the melanocytotoxic response.

• Authors: G Prota, M d'Ischia, D Mascagna
• Journal: Melanoma research (Melanoma Res) Vol. 4 Issue 6 Pg. 351-8 (Dec 1994) ISSN: 0960-8931 [Print] England
• PMID: 7703714 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Antineoplastic Agents
• Melanins

Topics

• Animals
• Antineoplastic Agents (pharmacology)
• Humans
• Melanins (biosynthesis)
• Melanoma (drug therapy, metabolism, secondary)
• Skin Neoplasms (drug therapy, metabolism, secondary)