Abstract | OBJECTIVE: METHODS: RESULTS:
BN 50730 was able partially to prevent the development of arthritis, and was also active on established arthritis. The joint arthritis scores of BN treated animals were significantly lower than those of the non-treated animals. The blood concentrations of PAF, PAF bound to lipoproteins (lipo-PAF), and its precursor, lyso-PAF, were not correlated with clinical variations. CONCLUSIONS: The present data demonstrate a therapeutic action of a PAF antagonist in experimental arthritis and suggest a critical role for PAF during the early stage of arthritis.
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Authors | P Hilliquin, J Natour, J Aissa, P Guinot, S Laoussadi, J Benveniste, C J Menkes, B Arnoux |
Journal | Annals of the rheumatic diseases
(Ann Rheum Dis)
Vol. 54
Issue 2
Pg. 140-3
(Feb 1995)
ISSN: 0003-4967 [Print] England |
PMID | 7702404
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Azepines
- Platelet Activating Factor
- Thienopyridines
- Triazoles
- BN 50730
- Carrageenan
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Topics |
- Animals
- Arthritis, Experimental
(chemically induced, prevention & control, therapy)
- Azepines
(therapeutic use)
- Carrageenan
- Injections, Intra-Articular
- Platelet Activating Factor
(antagonists & inhibitors)
- Rabbits
- Thienopyridines
- Triazoles
(therapeutic use)
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