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Occurrence of autoimmune antibodies to liver microsomal proteins associated with lethal hepatitis in LEC rats: effects of TJN-101 ((+)-(6S,7S,R-biar)- 5,6,7,8-tetrahydro-1,2,3,12-tetramethoxy-6,7-dimethyl-10,11- methylenedioxy-6-dibenzo[a,c]cyclooctenol) on the development of hepatitis and the autoantibodies.

Abstract
Long Evans Cinnamon (LEC) rats, that spontaneously develop hepatitis, were found to possess autoantibodies to liver microsomal proteins (anti-LM) before the development of hepatitis. Anti-LM antibody was assumed to appear in association with the lethal hepatitis in the LEC rats. Thus, the purpose of this study was to investigate the effects of an anti-hepatitis drug on the development of hepatitis and the occurrence of the antibody in LEC rats. Mortality, blood biochemical parameters and the titer of serum anti-LM antibody were measured. In control LEC rats, 4 of 8 rats died before 20 weeks of age. In rats treated with TJN-101 ((+)-(6S,7S,R-biar)-5,6,7,8-tetrahydro-1,2,3,12-tetramethoxy -6,7-dimethyl-10,11 - methylenedioxy-6-dibenzo[a,c]cyclooctenol), 4 of 7 rats died of hepatitis, but the time of death was delayed by 7-10 weeks compared to the control rats. The titer of the anti-LM antibody increased 3-7 weeks before death in the non-survivors in control and TJN-101-treated rats, supporting the idea that anti-LM antibody occurs in association with acute lethal hepatitis.
AuthorsT Yokoi, S Nagayama, R Kajiwara, Y Kawaguchi, T Aizawa, Y Otaki, M Aburada, T Kamataki
JournalToxicology letters (Toxicol Lett) Vol. 76 Issue 1 Pg. 33-8 (Feb 1995) ISSN: 0378-4274 [Print] Netherlands
PMID7701514 (Publication Type: Journal Article)
Chemical References
  • Autoantibodies
  • Cyclooctanes
  • Dioxoles
  • Lignans
  • schizandrol B
Topics
  • Animals
  • Autoantibodies (biosynthesis, drug effects)
  • Autoimmune Diseases (blood, immunology, mortality)
  • Body Weight (drug effects)
  • Cyclooctanes
  • Dioxoles (pharmacology)
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Hepatitis, Animal (blood, immunology, mortality)
  • Lignans
  • Microsomes, Liver (immunology)
  • Rats

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