Naturally occurring protein kinase C inhibitors; II. Isolation of oligomeric stilbenes from Caragana sinica.

Abstract	The oligomeric stilbenes (+)-alpha-viniferin (1), miyabenol C (2), and kobophenol A (3) have been isolated from Caragana sinica (Buchoz) Rehd (Leguminosae). (+)-alpha-Viniferin (1) and miyabenol C (2) exhibited protein kinase C inhibitory activity at low micromolar concentrations. (+)-alpha-Viniferin inhibited keratinocyte proliferation (0.4 microM) and free radical release in whole blood (47 microM), in vitro, and may be useful in treating hyperproliferative or inflammatory skin diseases.
Authors	P Kulanthaivel, W P Janzen, L M Ballas, J B Jiang, C Q Hu, J W Darges, J C Seldin, D J Cofield, L M Adams
Journal	Planta medica (Planta Med) Vol. 61 Issue 1 Pg. 41-4 (Feb 1995) ISSN: 0032-0943 [Print] Germany
PMID	7700990 (Publication Type: Journal Article)
Chemical References	Drugs, Chinese Herbal Stilbenes Protein Kinase C
Topics	Cells, Cultured Drugs, Chinese Herbal (chemistry, pharmacology) Humans Magnetic Resonance Spectroscopy Protein Kinase C (antagonists & inhibitors) Stilbenes (isolation & purification, pharmacology)

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