Role of endogenous cyclo(His-Pro) in cold-induced hypothermia in the desert rat (Mastomys natalensis).

Abstract

Central administration of exogenous cyclo(His-Pro) (CHP) is known to produce hypothermia in rodents. In the present study, we examined the role of endogenous CHP in cold-induced hypothermia in the desert rat, Mastomys natalensis. The results of these studies show that a rise in hypothalamic CHP content accompanied a decrease in rectal temperature during cold exposure. Immunoneutralization of endogenous CHP resulted in a significant decline in cold-induced hypothermia. In addition, central administration of cyclo(Ala-Gly), a structural analogue of CHP, also led to a decrease in cold-induced hypothermia. The results of these studies show that changes in endogenous CHP levels may affect body temperature regulation.

• Authors: R Shukla, N H Rahmani, H Mizuma, R C Srimal, C Prasad
• Journal: Peptides (Peptides) Vol. 15 Issue 8 Pg. 1471-4 ( 1994) ISSN: 0196-9781 [Print] United States
• PMID: 7700849 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Antibodies
• Diketopiperazines
• Peptides, Cyclic
• Piperazines
• 2,5-dioxopiperazine
• cyclo(alanyl-glycyl)
• histidyl-proline diketopiperazine

Topics

• Analysis of Variance
• Animals
• Antibodies (administration & dosage, pharmacology)
• Body Temperature (drug effects)
• Body Temperature Regulation
• Cerebral Ventricles (drug effects, physiology)
• Cold Temperature
• Desert Climate
• Diketopiperazines
• Hypothalamus (drug effects, physiology)
• Hypothermia, Induced
• Injections, Intraventricular
• Male
• Muridae (physiology)
• Peptides, Cyclic (administration & dosage, analysis, antagonists & inhibitors, pharmacology, physiology)
• Piperazines (administration & dosage, analysis, antagonists & inhibitors, pharmacology)
• Rats
• Species Specificity