Autoantibodies in Parry-Romberg syndrome: a serologic study of 14 patients.

Abstract

OBJECTIVE:

To determine autoantibody profiles of patients with Parry-Romberg syndrome (PRS).

METHODS:

Antinuclear antibodies (ANA) in 14 patients with PRS were studied by indirect immunofluorescence (IIF), immunodiffusion and immunoblotting. Antinative DNA antibodies and rheumatoid factor (RF) were also analyzed.

RESULTS:

ANA were positive in 8 patients (57%). The patterns of staining included nucleolar, nuclear speckled and homogeneous. Anticentromere antibodies were observed in 2 and antihistone antibodies in 3 sera. Rheumatoid factor was found in 5 (36%) sera. Antinative DNA or antibodies that precipitated rabbit thymus extract were not found in any patients.

CONCLUSION:

The serologic abnormalities observed in this study suggests that autoimmunity could play a pathogenic role in PRS.

• Authors: I Garcia-de la Torre, J Castello-Sendra, T Esgleyes-Ribot, G Martinez-Bonilla, J Guerrerosantos, M J Fritzler
• Journal: The Journal of rheumatology (J Rheumatol) Vol. 22 Issue 1 Pg. 73-7 (Jan 1995) ISSN: 0315-162X [Print] Canada
• PMID: 7699686 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antibodies, Antinuclear
• Antigens, Protozoan
• Histones
• Rheumatoid Factor

Topics

• Adolescent
• Adult
• Animals
• Antibodies, Antinuclear (blood)
• Antigens, Protozoan
• Centromere (immunology)
• Child
• Crithidia
• Female
• Histones (immunology)
• Humans
• Immunoblotting
• Incidence
• Male
• Rheumatoid Factor (blood)
• Scleroderma, Localized (blood, immunology)