Abstract | BACKGROUND/AIMS: METHODS: Eighty-four patients with PSC were randomized to receive 1 mg of colchicine daily (n = 44) or placebo (n = 40) in a double-blind 3-year study. The effect of treatment was evaluated through blind scoring of 10 variables in prestudy and poststudy liver biopsy specimens, daily recording of symptoms, and biochemical tests (serum bilirubin, alkaline phosphatase, aspartate aminotransferase, alanine aminotransferase, albumin, immunoglobulins, ceruloplasmin, alpha 1-antitrypsin, and plasma prothrombin levels) at 6-month intervals. RESULTS: There was no evidence of a favorable effect of colchicine on survival, symptoms, serum biochemistry, or liver histology in patients with PSC. CONCLUSIONS: One milligram of colchicine daily is ineffective in PSC.
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Authors | R Olsson, U Broomé, A Danielsson, I Hägerstrand, G Järnerot, L Lööf, H Prytz, B O Rydén, S Wallerstedt |
Journal | Gastroenterology
(Gastroenterology)
Vol. 108
Issue 4
Pg. 1199-203
(Apr 1995)
ISSN: 0016-5085 [Print] United States |
PMID | 7698589
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adult
- Cholangitis, Sclerosing
(drug therapy, mortality, pathology)
- Colchicine
(therapeutic use)
- Double-Blind Method
- Female
- Humans
- Liver
(pathology)
- Male
- Middle Aged
- Survival Rate
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